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Estrogen level monitoring in artificial frozen-thawed embryo transfer cycles using step-up regime without pituitary suppression: is it necessary?

Journal of Experimental & Clinical Assisted Reproduction volume 5, Article number: 4 (2008) Cite this article

Abstract

Background

To discuss the meaning of serum oestradiol monitoring in frozen embryo transfer cycle using hormone replacement without pretreatment with gonadotropin hormone (GnRH) agonist.

Methods

The data from two hundred twelve women undergoing two hundred seventy-four frozen-thawed embryo transfer (FET) cycles was included in this retrospective cohort study. They were detected of serum oestradiol levels and endometrium thicknesses during hormone supplement FET cycles and compared their pregnancy outcomes according to their oestradiol level on progesterone initiation day.

Results

Patients with different levels of serum oestradiol (percentile 0–25th, 25th–75th and 75th–100th) on progesterone initiation day yielded the endometrium thickness of 9.3 ± 0.12, 8.9 ± 0.07 and 9.1 ± 0.11 mm(P > 0.05) and the pregnancy rate of 32.2%, 38.4% and 36.3% (P > 0.05) respectively.

Conclusion

The serum estradiol level did not predict pregnancy success in hormone replacement FET cycles, suggesting that oestradiol monitoring in this method of endometrial preparation is unnecessary.

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Authors and Affiliations

  1. IVF-unit, Department of Obstetrics and Gynecology, RuiJin Hospital Affiliated to Shanghai Jiaotong University, PR China

    Zhihong Niu, Yun Feng, Yijuan Sun & Aijun Zhang

  2. Shanghai Institute of Planned Parenthood Research, Fudan University, Shanghai, PR China

    Zhihong Niu & Huiqin Zhang

Authors
  1. Zhihong Niu
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  2. Yun Feng
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  3. Yijuan Sun
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Correspondence to Yun Feng.

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The authors declare that they have no competing interests.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Niu, Z., Feng, Y., Sun, Y. et al. Estrogen level monitoring in artificial frozen-thawed embryo transfer cycles using step-up regime without pituitary suppression: is it necessary? . J Exp Clin Assist Reprod 5, 4 (2008). https://doi.org/10.1186/1743-1050-5-4

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  • DOI: https://doi.org/10.1186/1743-1050-5-4

Journal of Experimental & Clinical Assisted Reproduction

ISSN: 1743-1050