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Stage-variations of anandamide hydrolase activity in the mouse uterus during the natural oestrus cycle


Recent studies have demonstrated that the endogenous cannabinoids are important modulators of fertility in mammals. In particular, a role of the endocannabinoid system in early stages of embryo development, oviductal transport of embryos, pregnancy maintenance and labour has been demonstrated in rodents and/or in humans. In the present paper, we report the analysis of FAAH activity and protein content in the mouse uterus as a function of the natural oestrus cycle stages. Variations of FAAH activity are discussed in relationship to changes in sex steroid levels and to the possible action of AEA on remodelling of uterine tissues.


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This work was supported by the Italian MIUR PRIN grant 2004–2005.

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Correspondence to Massimo De Felici.

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The author(s) declare that they have no competing interests.

Authors' contributions

FGK and NB have produced most of the results and have been involved in drafting of the manuscript. MDF and MM have made equal contributions to conception and design and analysis and interpretation of data as well. All authors have given final approval of the version of the manuscript to be published.

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Klinger, F.G., Battista, N., De Felici, M. et al. Stage-variations of anandamide hydrolase activity in the mouse uterus during the natural oestrus cycle . J Exp Clin Assist Reprod 3, 3 (2006).

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