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Stage-variations of anandamide hydrolase activity in the mouse uterus during the natural oestrus cycle

Journal of Experimental & Clinical Assisted Reproduction volume 3, Article number: 3 (2006) Cite this article

Abstract

Recent studies have demonstrated that the endogenous cannabinoids are important modulators of fertility in mammals. In particular, a role of the endocannabinoid system in early stages of embryo development, oviductal transport of embryos, pregnancy maintenance and labour has been demonstrated in rodents and/or in humans. In the present paper, we report the analysis of FAAH activity and protein content in the mouse uterus as a function of the natural oestrus cycle stages. Variations of FAAH activity are discussed in relationship to changes in sex steroid levels and to the possible action of AEA on remodelling of uterine tissues.

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Acknowledgements

This work was supported by the Italian MIUR PRIN grant 2004–2005.

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Authors and Affiliations

  1. Department of Public Health and Cell Biology, University of Rome Tor Vergata, 00133, Rome, Italy

    Francesca G Klinger & Massimo De Felici

  2. Department of Biomedical Sciences, University of Teramo, 64100, Teramo, Italy

    Natalia Battista & Mauro Maccarrone

  3. IRCCS C. Mondino, Mondino-Tor Vergata Center for Experimental Neurobiology, 00133, Rome, Italy

    Mauro Maccarrone

Authors
  1. Francesca G Klinger
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  2. Natalia Battista
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  3. Massimo De Felici
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  4. Mauro Maccarrone
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Corresponding author

Correspondence to Massimo De Felici.

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Competing interests

The author(s) declare that they have no competing interests.

Authors' contributions

FGK and NB have produced most of the results and have been involved in drafting of the manuscript. MDF and MM have made equal contributions to conception and design and analysis and interpretation of data as well. All authors have given final approval of the version of the manuscript to be published.

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Open Access This article is published under license to BioMed Central Ltd. This is an Open Access article is distributed under the terms of the Creative Commons Attribution License ( https://creativecommons.org/licenses/by/2.0 ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Klinger, F.G., Battista, N., De Felici, M. et al. Stage-variations of anandamide hydrolase activity in the mouse uterus during the natural oestrus cycle . J Exp Clin Assist Reprod 3, 3 (2006). https://doi.org/10.1186/1743-1050-3-3

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  • DOI: https://doi.org/10.1186/1743-1050-3-3

Journal of Experimental & Clinical Assisted Reproduction

ISSN: 1743-1050