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Low-dose aspirin does not improve ovarian stimulation, endometrial response, or pregnancy rates for in vitro fertilization



The purpose of this study is to determine if low-dose aspirin improved ovarian stimulation, endometrial response, or IVF pregnancy rates in our program.


Retrospective analysis of 316 consecutive IVF cycles from 1995 through 2001. Aspirin 80 mg daily was initiated at the start of luteal leuprolide in 72 cycles. The 244 controls received no aspirin during treatment.


The live birth rate in aspirin users was 29%, slightly lower compared to 41% in the no aspirin control group (p = 0.07). Implantation rates were 21% with aspirin and 30% in the control population (p = 0.01). There was no difference in the maximal endometrial thickness between aspirin and non-aspirin groups. The two groups were similar regarding age, gonadotropin ampules, embryos, number of embryos transferred, prior parity, diagnosis, use of intracytoplasmic sperm injection, and stimulation protocol.


Low-dose aspirin was not beneficial to IVF patients in our program. Aspirin does not enhance endometrial thickness, augment the ovarian response, or improve pregnancy rates.


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We thank Howell Sasser, Ph.D., Director of Research Epidemiology, Dickson Institute at Carolinas Medical Center for his assistance with statistical evaluation.

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Corresponding author

Correspondence to Bradley S Hurst.

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Competing interests

The author(s) declare that they have no competing interests.

Authors' contributions

* BSH conceived of the study, participated in the analysis and interpretation of the data, and drafting and revising the manuscript. JTB made substantial contributions to the design and acquisition of data, and drafting the manuscript. PBM, MAP, TAL, and MLM made substantial contributions to the acquisition of data and revising the manuscript. All authors read and approved the final manuscript

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Hurst, B.S., Bhojwani, J.T., Marshburn, P.B. et al. Low-dose aspirin does not improve ovarian stimulation, endometrial response, or pregnancy rates for in vitro fertilization . J Exp Clin Assist Reprod 2, 8 (2005).

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  • aspirin
  • embryo transfer
  • endometrium
  • fertilization in vitro
  • infertility