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Impact of seasonal variation, age and smoking status on human semen parameters: The Massachusetts General Hospital experience
Journal of Experimental & Clinical Assisted Reproduction volume 1, Article number: 2 (2004)
To investigate the relationship of human semen parameters with season, age and smoking status.
The present study used data from subjects recruited into an ongoing cross-sectional study on the relationship between environmental agents and semen characteristics. Our population consisted of 306 patients who presented to the Vincent Memorial Andrology Laboratory of Massachusetts General Hospital for semen evaluation. Sperm concentration and motility were measured with computer aided sperm analysis (CASA). Sperm morphology was scored using Tygerberg Kruger strict criteria. Regression analyses were used to investigate the relationships between semen parameters and season, age and smoking status, adjusting for abstinence interval.
Sperm concentration in the spring was significantly higher than in winter, fall and summer (p < 0.05). There was suggestive evidence of higher sperm motility and percent of sperm with normal morphology in the spring than in the other seasons. There were no statistically significant relationships between semen parameters and smoking status, though current smokers tended to have lower sperm concentration. We also did not find a statistically significant relationship between age and semen parameters.
We found seasonal variations in sperm concentration and suggestive evidence of seasonal variation in sperm motility and percent sperm with normal morphology. Although smoking status was not a significant predictor of semen parameters, this may have been due to the small number of current smokers in the study.
Jeyendran RS: Interpretation of semen analysis results. A practical guide. 2000, Cambridge, UK: Cambridge University Press
Seibel MM: Infertility: A Comprehensive Test. In Diagnostic evaluation of an infertile couple. 1997, Stamford, Connecticut: Appleton & Lange, 5-2
Levine RJ, Bordson BL, Mathew RM, Brown MH, Stanley JM, Star TB: Deterioration of semen quality during summer in New Orleans. Fertil Steril. 1988, 49: 900-907.
Levine RJ: Male factors contributing to the seasonality of human reproduction. Ann N Y Acad Sci. 1994, 709: 29-45.
Saint Pol P, Beuscart R, Leroy-Martin B, Hermand E, Jablonski W: Circannual rhythms of sperm parameters of fertile men. Fertil Steril. 1989, 51: 1030-1033.
Centola GM, Eberly S: Seasonal variations and age-related changes in human sperm count, motility, motion parameters, morphology, and white blood cell concentration. Fertil Steril. 1999, 72: 803-808. 10.1016/S0015-0282(99)00395-7.
Haidl G, Jung A, Schill WB: Ageing and sperm function. Hum Reprod. 1996, 11: 558-560.
Kidd SA, Eskenazi B, Wyrobek AJ: Effects of male age on semen quality and fertility: a review of the literature. Fertil Steril. 2001, 75: 237-248. 10.1016/S0015-0282(00)01679-4.
Paulson RJ, Milligan RC, Sokol RZ: The lack of influence of age on male fertility. Am J Obstet Gynecol. 2001, 184: 818-822. 10.1067/mob.2001.113852.
Olsen J, Rachootin P, Schiodt AV, Damsbo N: Tobacco use, alcohol consumption and infertility. Int J Epidemiol. 1983, 12: 179-184.
Hughes EG, Brennan BG: Does cigarette smoking impair natural or assisted fecundity?. Fertil Steril. 1996, 66: 679-689.
Augood C, Duckitt K, Templeton AA: Smoking and female infertility: A systematic review and meta-analysis. Hum Reprod. 1998, 13: 1532-1539. 10.1093/humrep/13.6.1532.
Jensen TK, Henriksen TB, Hjollund NH, Scheike T, Kolstad H, Giwercman A, Ernst E, Bonde JP, Skakkebaek NE, Olsen J: Adult and prenatal exposures to tobacco smoke as risk indicators of fertility among 430 Danish couples. Am J Epidemiol. 1998, 148: 992-997.
Künzle R, Mueller MD, Hänggi W, Birkhäuser MH, Drescher H, Bersinger NA: Semen quality of male smokers and nonsmokers in infertile couples. Fertil Steril. 2003, 79: 287-291. 10.1016/S0015-0282(02)04664-2.
Bolumar F, Olsen J, Boldsen J: Smoking reduces fecundity: a European multicenter study on infertility and subfecundity. The European Study Group on Infertility and Subfecundity. Am J Epidemiol. 1996, 143: 578-587.
Chen Z, Toth T, Godfrey-Bailey L, Mercedat N, Schiff I, Hauser R: Seasonal variation and age-related changed in human semen parameters. J Androl. 2003, 24: 226-231.
World Health Organization: WHO Laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 1999, Cambridge, UK: Cambridge University Press, Fourth
Kruger TF, Acosta AA, Simmons KF, Swanson RJ, Matta JF, Oehninger S: Predictive value of abnormal sperm morphology in in vitro fertilization. Fertil Steril. 1988, 49: 112-117.
Levine RJ: Seasonal variation of semen quality and fertility. Scand J Work Environ Health. 1999, 25 (Suppl 1): 34-37.
Gyllenborg J, Skakkebaek NE, Nielsen NC, Keiding N, Giwercman A: Secular and seasonal changes in semen quality among young Danish men: a statistical analysis of semen samples from 1927 donor candidates during 1977–1995. Int J Androl. 1999, 22: 28-36. 10.1046/j.1365-2605.1999.00137.x.
Politoff L, Birkhauser M, Almendral A, Zorn A: New data confirming a circannual rhythm in spermatogenesis. Fertil Steril. 1989, 52: 486-489.
Mortimer D, Templeton AA, Lenton EA, Coleman RA: Annual patterns of human sperm production and semen quality. Arch Androl. 1983, 10: 1-5.
Henkel R, Menkveld R, Kleinhappl M, Schill WB: Seasonal changes in human sperm chromatin condensation. J Assist Reprod Genet. 2001, 18: 371-377. 10.1023/A:1016618405570.
Snyder PJ: Fewer sperm in the summer – it's not heat, it's.. N Engl J Med. 1990, 323: 54-56.
Hermo L, Clermont Y: How are germ cells produced and what factors control their production? . In: Handbook of Andrology. Edited by: Robaire B, Pryor J, Trasler J. 1995, Allen Press: Lawrence, KS,
Chia SE, Lim ST, Ho LM, Tay SK: Monthly variation in human semen quality in male partners of infertile women in the tropics. Hum Reprod. 2001, 16: 277-281. 10.1093/humrep/16.2.277.
Schwartz D, Mayaux MJ, Spira A, Moscato ML, Jouannet P, Czyglik F, David G: Semen characteristics as a function of age in 833 fertile men. Fertil Steril. 1983, 39: 530-535.
Vine MF, Margolin BH, Morrison HI, Hulka BS: Cigarette smoking and sperm density: A meta-analysis. Fertil Steril. 1994, 61: 35-43.
Chia SE, Tay SK, Lim ST: What constitutes a normal seminal analysis? Semen parameters of 243 fertile men. Hum Reprod. 1998, 13: 3394-3398. 10.1093/humrep/13.12.3394.
This study was funded by support from the National Institute of Environmental Health Sciences (grant # ES09718 and ES00002).
The authors thank Lucille Pothier, Computer Programmer at the Harvard School of Public Health, for assistance with data analysis. We also thank Ana Trisini, (Research Assistant at Harvard School of Public Health, Department of Environmental Health) for assistance with manuscript editing and Nelta Mercedat Lozius (Clinical Laboratory Assistant at Massachusetts General Hospital, Obstetrics & Gynecology Services) for assistance with analysis the samples.
ZC, LG-B, IS, and RH all contributed equally to this work and reviewed the manuscript.
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Chen, Z., Godfrey-Bailey, L., Schiff, I. et al. Impact of seasonal variation, age and smoking status on human semen parameters: The Massachusetts General Hospital experience . J Exp Clin Assist Reprod 1, 2 (2004). https://doi.org/10.1186/1743-1050-1-2